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KMID : 0361520010120010015
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Korean Journal of Psychopharmacology
2001 Volume.12 No. 1 p.15 ~ p.22
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The Use of Atypical Antipsychotics in Bipolar Disorder
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Abstract
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Atypical antipsychotics are the more effective and safer alternative to the common
practice of maintenance adjunctive treatment as well as acute adjuvant treatment with
traditional antipsychotics in patients with bipolar disorder. A few double-blind
controlled studies of acute mania found olanzapine or ziprasidone monotherapy to be
more effective than placebo, and the combination treatment of risperidone and mood
stabilizer was also more effective than placebo. Furthermore, clozapine has antimanic
and mood stabilizing effect for the treatment-refractory patients in acute manic and
maintenance phase. Olanzapine and risperidone are reported that they have long-term
mood stabilizing effect when they are used with mood stabilizers. At present,
combination treatment of atypical antipsychotics and mood stabilizer is generally
used. However, because each drug of such combinations causes sometimes bothersome and
potentially dangerous events as well as their interactions, the consideration for
their risk are needed.
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